Which Arduino Mega Version to choose? – Arduino Mega 2560 R3, Arduino Mega CH340 & Arduino Mega CP2102

The circled IC in all the three Arduino Megas is the one which is responsible for USB Serial communication and Program Uploading
Before you choose an Arduino Mega, you need to understand there are 3 different types of Mega versions related to USB interface and here they are

a) ATMega16U2 – Original Mega Compatible No additional Driver is needed.

b) CH340 – Additional Driver ch340 is needed.

c) CP2120 – Additional Driver Cp2102 is needed.

These additional drivers are needed to be installed only for one-time then there is no additional effort needed to use it.